Masayendisiti kubva kuYunivhesiti yeHiroshima vakawana komisheni nyowani mu broccoli nemamwe makabheji anogona kubatsira kurwisa mamwe marudzi egomarara.
DIM, kana 3,3'-diindolylmethane, inokonzera kufa kwesero rinodzorwa uye kudzokororwa kwezvikamu zvemasero mune fission yeast. Kana iyo DIM-induced kukuvara meshini inoramba iri muvanhu hazvisati zvazivikanwa.
"Takaona kuti kemikari yeDIM inokonzera chiitiko chitsva chebhayoloji chinokuvadza nyukireya mumbiriso yefission," akadaro Ueno, purofesa anobatana paHiroshima Healthy Aging Research Center paYunivhesiti yeHiroshima Graduate School of Integrated Life Sciences.
"Kutendeseka kwenyukireya membranes kwakakosha kune hutano hwevanhu," anodaro Ueno. "Kuchinja kunokonzera kukanganisa mu membrane yenyukireya kunowedzera kukwegura. Nuclear membranes zvakare inoputika uye kugadzirisa panguva yekutama kwegomarara."
Chikamu chekugadzirisa kwesero chinonzi autophagy, kana "kuzvidya." Iyi ndiyo nzira yekushatisa yezvikamu zvemasero, umo sero rinoshandisa zvikamu zvaro zvemukati kuchengetedza simba uye kugadzirisa maitiro ehupenyu.
Ueno akacherechedzawo kuti autophagy inobatanidzwa nezvose zviri zviviri kukwegura uye zvirwere zvine chokuita nezera. Kana sero rikakanganisika, rinofa semhedzisiro yehurongwa hwekufa hwakarongwa hunonzi apoptosis. Mazhinji cytotoxic cancer mishonga yegomarara inoita nekukurudzira apoptosis, saka kukwanisa kudzora maitiro aya kunogona kubatsira kuchengetedza nekuvandudza hutano hwevanhu, Ueno anodaro.
"Zvatinowana zvinoratidza kuti hamvuropu yenyukireya inogona kunge iri imwe yekutanga kunangwa neDIM," akadaro munyori Parwane Emami, mudzidzi wePhD paYunivhesiti yeHiroshima's Graduate School of Integrated Life Sciences.
Mhedziso iyi yakavakirwa pamushumo wekare kubva kuchikwata chekuGerman chekutsvagisa chakawana kuti kuwanda kweDIM kwakawedzera hupenyu hwefission yeast.
Zvingaite sezvisingaite kuti apoptosis-inducing compound inogona kuwedzera hupenyu hwechisikwa, asi Emami akatsanangura kuti DIM inongoratidzika kunge ichikurudzira hunhu uhu mukuparadzanisa maseru, senge cancer maseru. Kana vakafa, chipenyu chinogona kurarama kwenguva refu.
“Ongororo yakaitwa nevanhu ichangoburwa inoratidza kuti DIM mushonga unorwisa gomarara unoshanda nekupinza apoptosis mumhando dzakasiyana dzegomarara, kusanganisira rezamu, reprostate, remudumbu, uye repancreatic,” akadaro Ueno.
"Ongororo inoratidza zvakare kuti DIM inokonzera autophagy mumasero egomarara. Nekudaro, mhedzisiro yeautophagy pakugadzira bundu uye kufambira mberi haina kunyatsonzwisiswa. Kunzwisisa maitiro eapoptosis uye autophagy uchishandisa DIM mune fission mbiriso inogona kubatsira pakudzidza kenza yemunhu uye nzira dzehupenyu hurefu.
Vatsvagiri vacharamba vachidzidza basa reDIM mune fission yeast.
"Tinoda kunzwisisa kuti DIM inokuvadza sei nyukireya membrane ye fission yeast, izvo zvinogona kutungamira mukugadzirwa kwekutanga-mukirasi mushonga wekuuraya cancer maseru," akadaro Emami.
"Isu tinodawo kunzwisisa magadzirirwo ekuti DIM inobata sei autophagy mufission yeast, izvo zvinogona kubatsira pakunzwisisa nzira yekuwedzera hupenyu hwevanhu."